Senior Principal Scientist

Job Summary

A company is looking for a Senior Principal Scientist - Antibody-siRNA Bioanalytical & Biodistribution Strategy Lead.

Key Responsibilities

• Lead strategy to establish innovative bioanalytical platforms to measure antibody-siRNA conjugates in preclinical samples (in vitro and in vivo)
• Design, execute, and interpret results from in vivo studies characterizing pharmacokinetics and pharmacodynamic relationships
• Mentor and cross-train PKDM-BA scientific colleagues and foster cross-functional collaboration across Research and Development

Required Qualifications

• Doctorate degree in pharmacology, biochemistry, or a related scientific discipline with 3 years of industry experience, or a Master's degree with 6 years, or a Bachelor's degree with 8 years of industry experience
• Extensive knowledge of antibody-siRNA conjugate ADME and pharmacokinetics
• Experience investigating biodistribution and metabolism of siRNA conjugated to a tissue-targeting ligand
• Expertise in antibody-siRNA bioanalytical approaches and considerations
• Extensive experience with ligand binding assays and LC/MS bioanalytical platforms