Director of Computational DMPK

Job Summary

Leading a team of computational scientists, the remote full-time Director of Computational DMPK will manage the development and integration of metabolism models into a predictive toxicology platform, ensuring scientific rigor and overseeing project milestones.

Key responsibilities

• Lead a team of computational scientists and data curators, setting scientific direction and reviewing model standards
• Own the roadmap for metabolism models, determining readiness for platform integration and external review
• Design validation experiments and manage data strategy to ensure high-quality outputs and compliance with external scrutiny

Required qualifications

• PhD in computational chemistry, cheminformatics, drug metabolism, computational biology, pharmacology, or a related field
• Hands-on expertise in drug metabolism, including knowledge of CYP and non-CYP enzymes and enzyme kinetics
• Strong track record in computational modeling, including experience with machine learning and kinetic modeling
• Experience leading scientific teams and delivering against project milestones
• Demonstrated rigor in model validation and external benchmarking