Senior Associate Scientist, RNA

Job Summary

Driving scientific support for drug substance programs, the full-time Senior Associate Scientist, RNA will optimize and characterize RNA synthesis processes while collaborating with research and manufacturing teams in Cambridge, MA.

Key Responsibilities

• Apply high throughput and data-driven approaches for early optimization and characterization of RNA synthesis processes
• Support the definition and scale-up of RNA drug substance synthesis processes
• Collaborate with research teams to facilitate transitions from drug candidate nomination to clinical manufacturing

Required Qualifications

• Degree in Bio/Chemical Engineering, Bio/Chemistry, or a related field (BS with 4+ years or MS with 2+ years of experience)
• Knowledge of automated liquid handlers and small-scale stir tank reactors
• Experience with statistical design of experiments (DoE) and analysis of multivariate data
• Familiarity with process analytics and biophysical characterization techniques such as HPLC and gel electrophoresis
• Hands-on experience with liquid handling systems and high throughput workflow design is a plus